The extract of Gardenia Yellow pigment can be preliminarily refined by pectinase treatment, plate and frame filtration, centrifugation and other methods to remove pectin, protein and other macromolecular substances. However, Ginkgo Biloba Extract is necessary to remove the gardenoside, which causes the pigment to turn green. The commonly used refining methods are resin adsorption, ultrafiltration, reverse osmosis, supercritical fluid extraction, gel chromatography, lead salt precipitation, Bitter Melon Extract activated carbon adsorption and so on, but few of them are used in production. Foreign macroporous resin adsorption method has been applied to industrial production.

Separation and Barley Grass Powder: because the target products of gardenia yellow extracted from traditional Chinese medicine and food are different, the extraction solvents used are also different. Methanol is mainly used in traditional Chinese medicine, while water for food, such as saffron acid, saffron and gardenoside, are all water-soluble polar molecules. Some studies also show that alcohol is conducive to the extraction of saffron and saffron acid, while water is responsible for the extraction of gardenoside.

Since its production in 1961, Japan has imported Gardenia from Chinese mainland and Taiwan.